Exchanges or trading platforms on which the company has applied or agreed to have any of its securities admitted or traded.
The company’s shares are traded on AIM. There are no other exchanges or trading platforms on which the company has applied or agreed to have its shares admitted or traded. There are no restrictions on the transfer of securities.

Number of shares in issue
The company's issued share capital comprises 99,324,299 ordinary shares of 1p each. All of the shares are fully–paid; no shares are held as treasury shares. The percentage of shares not held in public hands is 9.72%

Identity and percentage holdings of significant shareholders
As at 24 June 2008, the company had been notified of the following holdings of 3% or more of the voting rights of the company (as shareholder and as the direct or indirect holder of financial instruments) pursuant to transitional provision 7 of the DTR Sourcebook of the Disclosure and Transparency Rules:

• Charles Stanley & Co. Limited – 5.24%
• Barclays plc – 4.79%
• Nigel Keen – 4.28%
• Medicis Capital Partners, GmbH – 3.49%
• Close Brothers Group plc – 3.41%
• Nexus Medical Partners II, LP – 3.40%

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